Efficacy and Safety of Vonoprazan and High-Dose Amoxicillin Dual Therapy for Rescue Treatment of Helicobacter pylori Infection: A Multicenter Randomized Controlled Trial
Overview
Paper Summary
This study found that a 14-day dual therapy of vonoprazan and high-dose amoxicillin (VHA) was as effective as the standard bismuth-containing quadruple therapy (BQT) for treating persistent H. pylori infection after initial treatment failure. Importantly, the VHA therapy resulted in significantly fewer side effects. Further research is needed to confirm these results in diverse populations and evaluate the role of antibiotic resistance testing.
Explain Like I'm Five
A new medicine combo for stomach bugs worked as well as the usual quadruple therapy, with fewer side effects!
Possible Conflicts of Interest
The authors declare no conflicts of interest.
Identified Limitations
Rating Explanation
This is a well-designed multicenter RCT with a clear methodology and substantial sample size. While limited by its regional focus and open-label design, the findings are valuable and contribute significantly to our understanding of H. pylori rescue treatment options. The lower incidence of adverse events with VHA is a clinically important advantage.
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