Viral effectors trigger innate immunity across the tree of life
Overview
Paper Summary
This review explores how viruses manipulate host cell pathways in similar ways across all domains of life (bacteria, plants, animals), triggering what's called "effector-triggered immunity." It highlights how viral infection disrupts key processes like transcription, protein function, and stress responses, and how these disruptions act as warning signals for the immune system.
Explain Like I'm Five
Viruses use similar sneaky tactics to infect all living things, from bacteria to humans. Our cells have developed ways to detect these tactics, like recognizing when a virus messes with our cell's machinery.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This review article provides a comprehensive and clear overview of a complex topic, highlighting intriguing parallels in how diverse organisms defend against viruses. While it relies on some speculation and does not present new experimental data, its synthesis of existing knowledge and conceptual framework are valuable contributions to the field.
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