This study compared proteomic changes in resistant (TSH1188) and susceptible (Catongo) cacao genotypes infected with *Moniliophthora perniciosa*, the causal agent of witches' broom disease. The resistant genotype displayed a more diverse and upregulated set of proteins related to oxidative stress, defense, and carbohydrate metabolism, suggesting a stronger and faster response to infection compared to the susceptible genotype.

None identified

This study makes a valuable contribution to the understanding of the molecular mechanisms underlying cacao resistance to WBD. The proteomic analysis provides insights into the complex interplay of proteins involved in defense and stress responses, and identifies potential resistance markers. The study is well-designed and executed, with appropriate statistical analyses. However, it has some limitations, such as the use of only two cacao genotypes and a single pathogen isolate, which reduces the generalizability of the findings. Furthermore, there is a lack of transcriptomic data to fully interpret the proteomic changes. Despite the limitations, this study is well-executed, and with its novelty, it warrants a rating of 4.