New guidelines for managing glomerular diseases focus on minimizing medication side effects, cost, and improving patient comfort.

Overview

Paper Summary › Explain Like I'm Five › Conflicts of Interest › Identified Limitations › Rating Explanation › Good to know › Topic Hierarchy › File Information ›

Paper Summary

Paperzilla title

The 2021 KDIGO Clinical Practice Guideline for the Management of Glomerular Diseases provides updated recommendations for diagnosis, treatment, and special considerations for several glomerular diseases. The guideline emphasizes minimizing adverse effects from immunosuppression while maximizing patient comfort and prioritizing the use of lower cost therapies where available. Research recommendations for all disease entities are also given.

Explain Like I'm Five

This is like when doctors make a new rulebook to help kids with tiny kidney filters work better. They want to make sure the medicine doesn't make you too sick and use medicines that aren't too expensive.

Possible Conflicts of Interest

Several Work Group members disclosed potential conflicts of interest, including consultancy or grant/research support from pharmaceutical companies. The full disclosure statements can be found in the 'Biographic and disclosure information' section.

Identified Limitations

Low-quality evidence

This article includes some practice guidelines and recommendations, which are not supported by scientific data.

Lack of RCTs

Most of the supportive evidence is of low or moderate quality because the clinical trials were conducted on subjects with a variety of glomerular diseases.

Lack of evidence

Some chapters do not have an evidence base from which to derive treatment suggestions.

Cost

The authors acknowledge that the cost of some medications included in the treatment guidelines remains high.

Availability

The authors also acknowledge that plasmapheresis is unavailable in some parts of the world, owing to the high cost and limited availability of replacement fluids.

Rating Explanation

The KDIGO 2021 guideline offers a comprehensive overview of clinical practice in glomerular diseases. It emphasizes a holistic approach, considering factors like patient comfort, medication costs, and side effects. However, the guideline also acknowledges limitations in current research and the need for more studies. Despite its limitations, the guideline provides valuable information for clinicians treating these diseases.

Good to know

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Topic Hierarchy

Domain: Health Sciences

Field: Medicine

Subfield: Nephrology

File Information

Original Title: KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases

Uploaded: July 14, 2025 at 11:10 AM

Privacy: Public