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Health Sciences › Medicine › Nephrology
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases
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Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
New guidelines for managing glomerular diseases focus on minimizing medication side effects, cost, and improving patient comfort.
The 2021 KDIGO Clinical Practice Guideline for the Management of Glomerular Diseases provides updated recommendations for diagnosis, treatment, and special considerations for several glomerular diseases. The guideline emphasizes minimizing adverse effects from immunosuppression while maximizing patient comfort and prioritizing the use of lower cost therapies where available. Research recommendations for all disease entities are also given.
Possible Conflicts of Interest
Several Work Group members disclosed potential conflicts of interest, including consultancy or grant/research support from pharmaceutical companies. The full disclosure statements can be found in the 'Biographic and disclosure information' section.
Identified Weaknesses
Low-quality evidence
This article includes some practice guidelines and recommendations, which are not supported by scientific data.
Lack of RCTs
Most of the supportive evidence is of low or moderate quality because the clinical trials were conducted on subjects with a variety of glomerular diseases.
Lack of evidence
Some chapters do not have an evidence base from which to derive treatment suggestions.
Cost
The authors acknowledge that the cost of some medications included in the treatment guidelines remains high.
Availability
The authors also acknowledge that plasmapheresis is unavailable in some parts of the world, owing to the high cost and limited availability of replacement fluids.
Rating Explanation
The KDIGO 2021 guideline offers a comprehensive overview of clinical practice in glomerular diseases. It emphasizes a holistic approach, considering factors like patient comfort, medication costs, and side effects. However, the guideline also acknowledges limitations in current research and the need for more studies. Despite its limitations, the guideline provides valuable information for clinicians treating these diseases.
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File Information
Original Title:
KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases
File Name:
1_s2.0_S0085253821005627_main.pdf
[download]
File Size:
10.14 MB
Uploaded:
July 14, 2025 at 11:10 AM
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