PAPERZILLA
Crunching Academic Papers into Bite-sized Insights.
About
Sign Out
← Back to papers
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
★
★
★
☆
☆
SHARE
Overview
Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
Good to know
Topic Hierarchy
File Information
Paper Summary
Paperzilla title
Want to Feel Younger? Try This Weird Diet (But Maybe Don't Get Your Hopes Up)
This study found that three cycles of a fasting-mimicking diet (FMD) were associated with a decrease in median biological age of 2.5 years, independent of weight loss, in a group of generally healthy adults. The FMD also reduced hepatic fat, improved insulin resistance, and shifted the immune profile toward a younger phenotype, although some of these findings were based on small subsets of participants.
Possible Conflicts of Interest
The experimental FMD was provided by L-Nutra Inc. USC has licensed intellectual property to L-Nutra. V.D.L. and T.E.M. have equity interest in L-Nutra but did not participate in data collection and analysis. V.D.L.'s equity will be assigned to charitable organizations.
Identified Weaknesses
Small sample size for some analyses
The sample size for some of the key findings, such as the effects on hepatic fat and diabetes markers, is quite small (5-13 participants), limiting the generalizability of these results. Larger studies are needed to confirm these effects.
Lack of control for other lifestyle factors
Although the study adjusted for weight loss, other lifestyle factors that could influence biological age (such as exercise, sleep, or stress levels) were not measured or controlled for. This makes it difficult to isolate the specific contribution of the FMD.
Dependence on a specific commercial product
The study relies on a specific, commercially available FMD product. It's unclear whether similar results would be achieved with other fasting or calorie restriction approaches.
Extrapolation of short-term data for long-term predictions
The long-term projections of life expectancy and mortality risk are based on simulations extrapolated from short-term data. The actual long-term effects of repeated FMD cycles are unknown and require further investigation.
Rating Explanation
This study shows some interesting preliminary findings about the potential benefits of a fasting-mimicking diet (FMD) on biological age and metabolic markers. However, several limitations (small sample sizes, lack of control for other lifestyle factors, reliance on a commercial product, and extrapolated long-term projections) warrant caution in interpreting the results and necessitate further research to confirm the findings and understand the underlying mechanisms.
Good to know
This is our free standard analysis. Paperzilla Pro fact-checks every citation, researches author backgrounds and funding sources, and uses advanced AI reasoning for more thorough insights.
Explore Pro →
Topic Hierarchy
File Information
Original Title:
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
File Name:
s41467-024-45260-9.pdf
[download]
File Size:
1.12 MB
Uploaded:
July 08, 2025 at 12:09 PM
Privacy:
🌐 Public
© 2025 Paperzilla. All rights reserved.