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Life Sciences › Immunology and Microbiology › Virology
Cross-Neutralizing Monoclonal Antibodies with Broad Activity Against Human and Bat-Derived SARS-Related Coronaviruses
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Promising Mouse Antibodies Neutralize Multiple SARS-CoV-2 Variants (in a Lab)
This study tested a panel of monoclonal antibodies in vitro and found several that potently neutralized a range of SARS-CoV-2 variants, including Omicron subvariants, as well as SARS-CoV-1 and bat coronaviruses like RaTG13 and WIV16. While the research used pseudotyped viruses and lacks in vivo data, the findings suggest potential for developing broadly effective antibody cocktails.
Possible Conflicts of Interest
None identified.
Identified Weaknesses
In vitro and Pseudotyped Virus Limitations
The study relies on in vitro and pseudotyped virus assays, which may not perfectly reflect real-world effectiveness in humans.
Lack of In Vivo Testing
The lack of in vivo testing (e.g., in animal models) limits the ability to draw conclusions about clinical efficacy.
Limited Mechanistic Investigation
The study doesn't thoroughly investigate the mechanisms of action of the identified antibodies, limiting deeper understanding.
Rating Explanation
The study presents a well-designed investigation of monoclonal antibody effectiveness against various SARS-CoV-2 variants and other coronaviruses in vitro. The use of multiple assays strengthens the findings. While limited by its in vitro nature and lack of in vivo data, it offers valuable insights for therapeutic development. No obvious conflicts of interest were found.
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Topic Hierarchy
File Information
Original Title:
Cross-Neutralizing Monoclonal Antibodies with Broad Activity Against Human and Bat-Derived SARS-Related Coronaviruses
File Name:
paper_238.pdf
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File Size:
11.90 MB
Uploaded:
August 15, 2025 at 06:50 PM
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