Cross-Neutralizing Monoclonal Antibodies with Broad Activity Against Human and Bat-Derived SARS-Related Coronaviruses
Overview
Paper Summary
This study tested a panel of monoclonal antibodies in vitro and found several that potently neutralized a range of SARS-CoV-2 variants, including Omicron subvariants, as well as SARS-CoV-1 and bat coronaviruses like RaTG13 and WIV16. While the research used pseudotyped viruses and lacks in vivo data, the findings suggest potential for developing broadly effective antibody cocktails.
Explain Like I'm Five
This study tested antibodies from mice against different SARS-CoV-2 variants and related viruses in a lab setting. Some antibodies worked well against multiple variants, suggesting they could be used in antibody cocktails to treat infections.
Possible Conflicts of Interest
None identified.
Identified Limitations
Rating Explanation
The study presents a well-designed investigation of monoclonal antibody effectiveness against various SARS-CoV-2 variants and other coronaviruses in vitro. The use of multiple assays strengthens the findings. While limited by its in vitro nature and lack of in vivo data, it offers valuable insights for therapeutic development. No obvious conflicts of interest were found.
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