Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism
Overview
Paper Summary
This study demonstrates that the transcription factor ATF4 activates a mitochondrial metabolic defense against the parasite *Toxoplasma gondii* by increasing mitochondrial one-carbon metabolism, which uses folate, an essential B vitamin. This increased folate use restricts the parasite's access to folate, which is crucial for its own growth. In a mouse model, ATF4 activation was linked to a host-protective response.
Explain Like I'm Five
A protein called ATF4 helps our cells use a vitamin called folate to keep a parasite called *Toxoplasma gondii* from growing too much. It's like ATF4 is making our cells better at grabbing the folate so the parasite can't have it.
Possible Conflicts of Interest
None identified.
Identified Limitations
Rating Explanation
This study uses a clear methodology to explore a novel mechanism of metabolic immunity to Toxoplasma infection. The research is well-executed, providing compelling in vitro and in vivo data. The identification of ATF4 as a key regulator of this defense mechanism offers potential avenues for therapeutic intervention, although further research is needed to translate these findings into clinical applications.
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