Upcoming drug targets for kidney protective effects in chronic kidney disease

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Paper Summary

Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Promising New Drugs Could Be Game-Changers for Chronic Kidney Disease

This review highlights several new drug targets for chronic kidney disease (CKD) that show promise in slowing disease progression, particularly in patients with type 2 diabetes. These include glucagon-like peptide-1 receptor agonists (GLP1RA), aldosterone synthase inhibitors (ASI), endothelin receptor antagonists (ERA), and soluble guanylate cyclase (SGC) activators. Further research is needed to fully understand the mechanisms of action and optimize their clinical use.

Possible Conflicts of Interest

The review discloses funding from Bayer AG for the supplement in which it was published. Additionally, Dr. D. Z. I. Cherney, one of the authors, reports having received consulting fees, speaking honoraria, and operating funds from multiple pharmaceutical companies related to the therapies discussed in the review, including AbbVie, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim-Lilly, Bristol-Myers Squibb, Janssen, JNJ, MAZE, Merck & Co., Inc., Mitsubishi-Tanabe, Novo Nordisk, Otsuka, Prometic, and Sanofi. He has also served as a scientific advisor for several of these companies.

Identified Weaknesses

Variability in clinical trial design

This review summarizes findings from clinical trials, which vary in their design and participant populations. Generalizability may be limited depending on the specific study.

Incomplete mechanistic understanding

The mechanisms of action for some of the promising drugs are still under investigation, which makes it difficult to draw definitive conclusions about their long-term effectiveness and safety.

Lack of availability

Not all the drugs mentioned are approved for CKD, some are under investigation.

Rating Explanation

This review summarizes promising new treatments for chronic kidney disease supported by clinical trial data. While some of the drugs discussed are already in use for related conditions like type 2 diabetes, their potential in specifically addressing CKD progression is a noteworthy advancement. The disclosed industry funding and potential conflicts of interest, though acknowledged, slightly lower the overall rating.

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