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Health Sciences › Medicine › Rehabilitation
A single bout of resistance or high-intensity interval training increases anti-cancer myokines and suppresses cancer cell growth in vitro in survivors of breast cancer
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Pumping Iron vs. Quick Bursts: Which Exercise Style Best Fights Breast Cancer Cells (In a Dish)?
This study examined how a single session of either resistance training (RT) or high-intensity interval training (HIIT) affected anti-cancer molecules (myokines) and breast cancer cell growth in a lab setting using blood samples from breast cancer survivors. Both RT and HIIT increased myokine levels and reduced cancer cell growth in the lab, with HIIT showing slightly stronger effects on cell growth immediately after exercise.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Limited myokine analysis
The study only measured a few myokines. Other important molecules involved in cancer might be affected by exercise too.
Specific cancer cell line
The study only used one type of breast cancer cell (MDA-MB-231). Results might differ for other types of breast cancer.
In vitro study
The study used cancer cells in a dish, which doesn't fully represent the complexity of a living body and how cancer behaves in a real person.
Single bout of exercise
The study only looked at the immediate effects of a single workout. It's unknown if these effects are long-lasting or translate to real-world cancer outcomes.
Lack of information on medications
The study didn't collect information on participants' medications, some of which could influence myokine or immune responses.
Rating Explanation
This is a pilot study with a decent sample size and randomized design, providing preliminary insights into the acute effects of exercise on myokines and cancer cell growth in breast cancer survivors. However, the in vitro nature of the study, its limited scope to a single exercise bout, and use of only one cancer cell line significantly limit the generalizability of the findings. Thus, a rating of 3 is appropriate.
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File Information
Original Title:
A single bout of resistance or high-intensity interval training increases anti-cancer myokines and suppresses cancer cell growth in vitro in survivors of breast cancer
File Name:
paper_1738.pdf
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File Size:
1.26 MB
Uploaded:
September 20, 2025 at 05:18 PM
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