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Health Sciences › Medicine › Oncology
Metal complexes as a promising source for new antibiotics
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Metals for Microbes: Exploring the Untapped Potential of Metal Complexes as Antibiotics
This study investigated the antimicrobial activity of 906 metal-containing compounds and found a significantly higher hit-rate (9.9% non-toxic) compared to purely organic molecules (0.87%). Out of these, 30 non-toxic compounds displayed promising activity against various bacterial and fungal strains, highlighting the potential of metal complexes as a source for new antibiotics.
Possible Conflicts of Interest
The authors acknowledge funding from various sources, including the Wellcome Trust, The University of Queensland, and several other organizations. Additionally, one author (MAC) holds positions at both an academic institution and a pharmaceutical company (Inflazome Ltd). While the study declares no conflicts, the involvement of pharmaceutical interests warrants careful consideration and potential further scrutiny.
Identified Weaknesses
Lack of Purity Control
The study acknowledges the limitation of not performing quality control checks on the purity of the submitted compounds due to the high volume received. This raises the possibility of false positives and necessitates thorough verification of promising compounds before further development.
Limited Structure-Activity Relationship Analysis
While the study presents a large dataset, it acknowledges the sparsity of data for specific structure-activity relationship evaluation. This limits the ability to draw definitive conclusions about the influence of specific metal and ligand combinations on antimicrobial activity.
Lack of In Vivo Data
The study primarily focuses on in vitro activity and acknowledges the need for further investigations, especially regarding in vivo stability and toxicity, which are crucial for clinical translation.
Rating Explanation
This study presents a valuable contribution to the field of antimicrobial research by exploring the often-overlooked potential of metal complexes. The large dataset analyzed and the identification of several non-toxic compounds with promising activity warrant a strong rating. However, the limitations regarding structure-activity analysis, lack of in vivo data, and potential conflicts of interest prevent a top rating.
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File Information
Original Title:
Metal complexes as a promising source for new antibiotics
File Name:
c9sc06460e.pdf
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File Size:
2.21 MB
Uploaded:
July 14, 2025 at 10:39 AM
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