SUPPLEMENTARY INFORMATION

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Paper Summary

Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Supplementary Data on Gene Expression and Tumor Characteristics in Oral Cancer

This supplementary information provides additional data tables for a study on oral cancer, including gene expression profiles, tumor-initiating cell frequencies, and the effects of a CD36 antibody. The data details gene expression differences in various cell populations, glucose levels and weight in mice fed different diets, metastasis-initiating cell frequencies, and blood parameters measured in treated and untreated mice.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Lack of Standalone Information

This supplementary material does not provide sufficient context or independent conclusions without the main article. It is impossible to determine the methodology's soundness or the significance of the findings without the primary publication.

Limited Interpretation

The tables provide data points, but offer minimal explanation or interpretation of their significance. It's hard to gauge the impact of the observed differences without further analysis.

Reliance on Mouse Models

Some data comes from mouse models, which limits the direct applicability of the findings to humans. The supplementary material does not address the limitations of mouse models in relation to human oral cancer.

Rating Explanation

This supplementary information provides valuable data for the main study but is impossible to evaluate independently. It is dependent on the primary publication for context and conclusions. The use of mouse models limits human relevance, justifying a rating of 3.

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