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Health Sciences › Medicine › Orthopedics and Sports Medicine
The clinician's guide to prevention and treatment of osteoporosis
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Don't break a hip! Your bones need calcium, vitamin D, and exercise, or else drugs. Oh, and don't fall.
Osteoporosis is a significant public health problem, but fractures are largely preventable with early diagnosis and treatment. This clinician's guide provides comprehensive recommendations for prevention, diagnosis, and treatment of osteoporosis, incorporating lifestyle modifications, pharmacologic therapies, and strategies to promote adherence.
Possible Conflicts of Interest
Some authors have received funding or consulting fees from pharmaceutical companies involved in osteoporosis treatment, including Radius, Amgen, Mereo, Bindex, Alexion, and UCB. The BHOF, which developed this guide, also receives funding from various sources.
Identified Weaknesses
Lack of causal evidence from RCTs for exercise/fall prevention
The observational nature of the cited research limits conclusions about causal relationships between interventions and fracture risk reduction.
Lack of comparative treatment data
Limited data for comparing efficacy of different treatments in postmenopausal osteoporosis and even less for men with osteoporosis.
Implementation of guidelines in clinical practice
The complexities of osteoporosis diagnosis and management can pose significant challenges for patients and health professionals alike, particularly in today's fragmented healthcare environment.
Implementation gap
Despite the existence of efficacious treatments, many patients do not receive timely or appropriate interventions.
Uncertainty about treatment duration
Uncertainty persists regarding the optimal duration of treatment with bisphosphonates and other antiresorptive agents, as well as the management of drug holidays.
Limited evidence for non-pharmacologic interventions
Limited research exists on the effectiveness of non-pharmacological pain management strategies for chronic pain related to osteoporotic fractures.
Rating Explanation
This comprehensive guide provides evidence-based recommendations for osteoporosis prevention and treatment, incorporating recent research and expert consensus. While there are limitations regarding the strength of evidence for some recommendations and the translation of guidelines into practice, the guide offers valuable insights for clinicians and promotes a patient-centered approach to managing this complex disease. The acknowledged conflicts of interest are noted but do not significantly detract from the overall quality and value of the guide.
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Topic Hierarchy
File Information
Original Title:
The clinician's guide to prevention and treatment of osteoporosis
File Name:
s00198-021-05900-y.pdf
[download]
File Size:
2.23 MB
Uploaded:
July 14, 2025 at 10:41 AM
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