Molecularly imprinted polymers (MIPs) offer a promising, low-cost alternative to bioreceptors in sensors and assays, boasting robust stability and straightforward synthesis. Despite their potential, widespread commercialization of MIP-based systems has been hampered by challenges in mass production and integration into user-friendly devices, but recent advances in commercial MIP synthesis and assay development are paving the way for broader adoption in various fields, including diagnostics, environmental monitoring, and food safety.

The authors declare a potential conflict of interest as they are working on founding a company, SENSIP BV, based on their thermal sensing technique. However, this is disclosed transparently in the manuscript.

The paper provides a comprehensive overview of MIP technology and its application in sensors and assays. The discussion of commercialization challenges and opportunities is insightful, though more in-depth analysis in certain areas would strengthen the paper further. The declared conflict of interest is appropriately handled.