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Health Sciences › Medicine › Neurology
Infections with Chlamydia pneumoniae and SARS-CoV-2 and Alzheimer's disease pathogenesis
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Paper Summary
Paperzilla title
Sniffles, Bugs, and Brain Fog: Could Cpn and SARS-CoV-2 be AD Culprits?
This review explores the potential link between respiratory infections (Cpn and SARS-CoV-2) and Alzheimer's disease. Both pathogens can access the brain, potentially triggering neuroinflammation and exacerbating AD pathologies like amyloid plaques and tau tangles, especially in individuals with APOEɛ4 genetic susceptibility.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Sex differences
More studies are needed to understand the sex differences and vulnerabilities in AD and infections.
Role of APOE4
More studies are needed to confirm the role of APOE4 in Cpn and SARS-CoV-2 infection and AD.
Correlation vs. Causation
The review relies on correlational data and association studies, thus causality cannot be inferred.
Polymicrobial infection analysis
More research needs to be conducted on the effects of polymicrobial infections, co-infections and viral persistence in the development and progression of AD.
Rating Explanation
This is a thorough review of the literature on the potential roles of Cpn and SARS-CoV-2 in AD pathogenesis. It presents compelling evidence for the involvement of these pathogens in neuroinflammation and neuronal damage, offering potential diagnostic avenues. While causality isn't definitively established, the hypotheses presented are well-supported and warrant further investigation.
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File Information
Original Title:
Infections with Chlamydia pneumoniae and SARS-CoV-2 and Alzheimer's disease pathogenesis
File Name:
fnagi-1-1587782 (1).pdf
[download]
File Size:
3.25 MB
Uploaded:
July 18, 2025 at 02:59 PM
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