Infections with Chlamydia pneumoniae and SARS-CoV-2 and Alzheimer's disease pathogenesis
Overview
Paper Summary
This review explores the potential link between respiratory infections (Cpn and SARS-CoV-2) and Alzheimer's disease. Both pathogens can access the brain, potentially triggering neuroinflammation and exacerbating AD pathologies like amyloid plaques and tau tangles, especially in individuals with APOEɛ4 genetic susceptibility.
Explain Like I'm Five
Scientists found that germs from bad colds, like COVID-19, might get into your brain. Once there, they could make your brain sick and messy, which might make old people forget things faster, especially for some people.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This is a thorough review of the literature on the potential roles of Cpn and SARS-CoV-2 in AD pathogenesis. It presents compelling evidence for the involvement of these pathogens in neuroinflammation and neuronal damage, offering potential diagnostic avenues. While causality isn't definitively established, the hypotheses presented are well-supported and warrant further investigation.
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