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Life SciencesAgricultural and Biological SciencesEcology, Evolution, Behavior and Systematics

Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Got Milk? Prehistoric Europeans with Lactase Persistence Were Taller!
This study found that Neolithic populations were only slightly shorter than pre-agricultural populations and that this difference was at least partially due to genetics. Surprisingly, the lactase persistence allele was strongly associated with increased height in ancient individuals, even though it is not associated with height today.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Limited transferability of polygenic scores
The study acknowledges the limited transferability of polygenic scores across ancestry groups and time periods, potentially impacting the accuracy of stature predictions.
Simplified categorization of time periods
The classification of individuals into pre-agricultural, Neolithic, and post-Neolithic periods based on archaeological assessments may not perfectly capture the complexity of subsistence strategies and transitions.
Limited scope of phenotypic analysis
The study focuses solely on femur length as a proxy for stature, neglecting other potential skeletal indicators of health and nutrition.
Rating Explanation
This study provides a valuable contribution to understanding the evolutionary history of human height by integrating genomic and phenotypic data from a large sample of ancient individuals. The findings challenge established hypotheses about the Neolithic stature decline and reveal a surprising association between lactase persistence and height in ancient populations. While there are some limitations regarding the simplified categorization of time periods and reliance on femur length as the sole stature indicator, the study's robust methodology and novel findings warrant a strong rating. The lack of any identified conflicts of interest further supports this evaluation.
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File Information
Original Title:
Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans
File Name:
2025.07.11.664181v1.full.pdf
[download]
File Size:
5.38 MB
Uploaded:
July 18, 2025 at 10:23 AM
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🌐 Public
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