A portrait of the infected cell: how SARS-CoV-2 infection reshapes cellular processes and pathways

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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SARS-CoV-2 Hijacks Cellular Machinery for its Own Evil Purposes!

This review examines how SARS-CoV-2 alters cellular pathways, particularly those related to the ER, autophagy, and lipid metabolism. The virus manipulates these pathways to create a favorable environment for replication, including the formation of replication organelles and evasion of host defenses. Further research is needed to fully understand the complex interplay between the virus and host and its impact on disease pathogenesis.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Limited in vivo data

The review primarily focuses on in vitro studies and some in vivo findings, which may not fully represent the complexity of SARS-CoV-2 infection and host responses in a living organism.

Lack of detailed mechanistic insights

While the review describes the interaction between SARS-CoV-2 and several cellular pathways, it doesn't provide a comprehensive mechanistic understanding of how these interactions contribute to the overall pathogenesis of COVID-19.

Limited scope of pathways discussed

The review primarily focuses on well-studied pathways, and less is known about the involvement of other potentially relevant cellular processes during SARS-CoV-2 infection.

Rating Explanation

This review provides a strong overview of key cellular processes hijacked by SARS-CoV-2, using valid scientific evidence from various published studies. While relying heavily on in vitro data, the review effectively synthesizes current knowledge and highlights crucial areas for future research.

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