Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
Overview
Paper Summary
Overexpression of the protein synthesis initiation factor eIF4E in microglia, but not neurons or astrocytes, leads to autism-like behaviors in male mice. This effect is sex-specific, with male mice showing increased microglial density and size, altered synaptic function, and social deficits, while female mice remain largely unaffected.
Explain Like I'm Five
Scientists found that if certain helper cells in boy mice brains make too much of something, it can cause them to act in ways similar to autism. Girl mice don't have this problem.
Possible Conflicts of Interest
None identified.
Identified Limitations
Rating Explanation
This is a well-executed study that identifies a novel cellular mechanism contributing to ASD-like behaviors in mice. The findings are significant and have implications for understanding the role of microglia in neurodevelopmental disorders. The methodology is rigorous, including a combination of genetic manipulation, behavioral assays, immunohistochemistry, electron microscopy, and electrophysiology. Although the study has limitations related to animal models and mechanistic detail, the overall quality and impact are high.
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