Identification of early predictors of clinical remission in primary membranous nephropathy: a post-hoc analysis of the STARMEN trial
Overview
Paper Summary
In a small post-hoc analysis of a clinical trial, researchers found that a combination of 24-hour proteinuria, serum creatinine, and immunological status at 3 months after starting immunosuppressive therapy could predict clinical remission of membranous nephropathy at 2 years. The combined model performed better than individual markers, but the small sample size, limited follow-up, and potential conflicts of interest require further validation in larger studies.
Explain Like I'm Five
Combining proteinuria, creatinine, and immune response data at 3 months after starting immunosuppressive therapy can predict remission from membranous nephropathy better than using each measure individually.
Possible Conflicts of Interest
Several authors declared receiving consulting fees, payments for lectures, grants, royalties, or participation in advisory boards from pharmaceutical companies like Novartis, SOBI, Alexion, Vifor, GSK, Otsuka, Samsung, Sanofi, Mundipharma, and AstraZeneca. These potential conflicts of interest should be considered when interpreting the results.
Identified Limitations
Rating Explanation
The study presents a potentially useful predictive model, but the small sample size, post-hoc nature of the analysis, short follow-up, and potential conflicts of interest warrant a moderate rating. External validation is crucial.
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