PAPERZILLA
Crunching Academic Papers into Bite-sized Insights.
About
Sign Out
← Back to papers
Health Sciences › Medicine › Dermatology
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
★
★
★
★
☆
SHARE
Overview
Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
Good to know
Topic Hierarchy
File Information
Paper Summary
Paperzilla title
Old Skin Fibroblasts Forget Their Jobs (and Can't Talk to Their Neighbors)
This study used single-cell RNA sequencing to identify four main subpopulations of fibroblasts in human skin. These subpopulations show specialized functions and locations, and their functional identities become less defined with age, including a reduced ability to interact with other skin cells like keratinocytes. These changes may contribute to the characteristic features of aging skin.
Possible Conflicts of Interest
F.L. received consultation fees from Beiersdorf AG.
Identified Weaknesses
Limited generalizability due to all-male sample
The study is limited to male participants, which may not represent the aging process in female skin. Hormonal and other biological differences could influence age-related changes in fibroblasts.
Lack of control for lifestyle factors
The study does not account for lifestyle factors (e.g., smoking, diet, exercise) that could influence skin aging and fibroblast function. These factors could confound the observed age-related changes.
Reliance on predicted cell-cell interactions
The study relies on predictions of cell-cell interactions based on gene expression. Direct experimental validation of these interactions is needed to confirm their functional relevance.
Rating Explanation
This is a well-executed study using advanced single-cell technology to provide novel insights into skin aging. While some limitations exist (e.g., male-only sample, lack of lifestyle control), the findings are robust and have important implications for understanding age-related skin changes. The conflict of interest is noted but does not appear to significantly compromise the study's integrity.
Good to know
This is our free standard analysis. Paperzilla Pro fact-checks every citation, researches author backgrounds and funding sources, and uses advanced AI reasoning for more thorough insights.
Explore Pro →
Topic Hierarchy
File Information
Original Title:
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
File Name:
s42003-020-0922-4.pdf
[download]
File Size:
11.33 MB
Uploaded:
July 14, 2025 at 10:55 AM
Privacy:
🌐 Public
© 2025 Paperzilla. All rights reserved.