Pathophysiology of chronic kidney disease-mineral bone disorder (CKD-MBD): from adaptive to maladaptive mineral homeostasis

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Identified Weaknesses

Rating Explanation

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Paper Summary

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CKD-MBD: When Your Kidneys Mess with Your Bones (and Heart)

This review discusses chronic kidney disease-mineral bone disorder (CKD-MBD), a complex condition affecting people with reduced kidney function. It explores the interplay between disrupted mineral balance, bone health issues, and cardiovascular problems in CKD, emphasizing the roles of fibroblast growth factor 23 (FGF-23), parathyroid hormone (PTH), and other factors.

Possible Conflicts of Interest

Antonio Bellasi attended advisory boards and received speaking honoraria from Amgen, Sanofi, and Sanifit. The paper was also funded by an educational grant from CSL Vifor.

Identified Weaknesses

Review Article

This is a review article summarizing existing research, rather than presenting new experimental findings. While valuable for consolidating knowledge, it doesn't advance the field with original data.

Limited Mechanistic Detail

While the review covers various factors involved in CKD-MBD, it doesn't delve deep into specific molecular mechanisms or pathways, hindering a more precise understanding of the disease's complexity.

Lack of Focus on Treatment Advances

The review briefly mentions future perspectives but lacks detailed discussion of current or emerging treatments for CKD-MBD. This limits its clinical value for healthcare professionals seeking treatment updates.

Rating Explanation

This review provides a comprehensive overview of CKD-MBD, covering key factors and pathophysiological mechanisms. While it doesn't offer new experimental data, it synthesizes existing research effectively. The disclosed conflict of interest and lack of in-depth mechanistic detail slightly lower the rating, but overall it's a valuable resource for understanding this complex condition.

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