Pathophysiology of chronic kidney disease-mineral bone disorder (CKD-MBD): from adaptive to maladaptive mineral homeostasis
Overview
Paper Summary
This review discusses chronic kidney disease-mineral bone disorder (CKD-MBD), a complex condition affecting people with reduced kidney function. It explores the interplay between disrupted mineral balance, bone health issues, and cardiovascular problems in CKD, emphasizing the roles of fibroblast growth factor 23 (FGF-23), parathyroid hormone (PTH), and other factors.
Explain Like I'm Five
When your kidneys don't work well, they can't balance important minerals like calcium and phosphorus. This imbalance can weaken your bones and cause dangerous build-up in your blood vessels.
Possible Conflicts of Interest
Antonio Bellasi attended advisory boards and received speaking honoraria from Amgen, Sanofi, and Sanifit. The paper was also funded by an educational grant from CSL Vifor.
Identified Limitations
Rating Explanation
This review provides a comprehensive overview of CKD-MBD, covering key factors and pathophysiological mechanisms. While it doesn't offer new experimental data, it synthesizes existing research effectively. The disclosed conflict of interest and lack of in-depth mechanistic detail slightly lower the rating, but overall it's a valuable resource for understanding this complex condition.
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