Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer

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Paper Summary

Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Ivermectin Shows Promise Against Breast Cancer (in Mice)

This study, conducted on mice, suggests that ivermectin can make breast tumors more responsive to immunotherapy by increasing T-cell infiltration and synergizing with anti-PD-1 treatment. The combined treatment resulted in complete tumor regression in some mice and prevented tumor recurrence when re-challenged with cancer cells.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Animal Model

The research was conducted on mice, and the results may not translate directly to humans.

Specific Cancer Type

The study focuses on triple-negative breast cancer (TNBC), and ivermectin's effects may differ in other breast cancer subtypes.

Limited Mechanistic Understanding

While the study suggests a mechanism of action for ivermectin, further research is needed to fully understand how it works and its long-term effects.

Rating Explanation

The study presents compelling preclinical data with a reasonable sample size and appropriate controls. The combination therapy showed impressive results in multiple clinically relevant settings in the mouse model. However, the reliance on a mouse model limits the immediate applicability to human patients, hence a rating of 4.

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