Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation
Overview
Paper Summary
This small study found similarities in how Long COVID (PASC) and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) patients experience exercise limitations, potentially due to problems with how oxygen gets to and is used by muscles. The researchers also found evidence suggesting that small fiber neuropathy in the skin might be related to these exercise issues in some PASC patients.
Explain Like I'm Five
Long COVID and CFS/ME patients seem to have trouble getting enough oxygen to their muscles during exercise, making it hard for them to work out. This might be because of problems with the small nerves in their skin and muscles.
Possible Conflicts of Interest
Dr. Levine has a financial interest in Corinthian Reference Labs and CND Life Sciences. Dr. Rischard reports consulting relationships with several companies related to heart/lung conditions and receives research support from various pharmaceutical companies.
Identified Limitations
Rating Explanation
While this study offers interesting insights into the physiological similarities between PASC and CFS/ME during exercise, the small sample size, control group issues, and potential for selection bias significantly limit the generalizability of the findings. The reported conflicts of interest also need to be considered.
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