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Physical Sciences › Materials Science › Biomaterials
Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Macrophage-Like Nanoparticles Sneak In, Deliver Drugs, and Clean Up Inflammation: A New Approach to Treating Clogged Arteries
This study developed macrophage membrane-coated, ROS-responsive nanoparticles for targeted drug delivery and cytokine sequestration to treat atherosclerosis. The nanoparticles successfully targeted atherosclerotic plaques in mice, released the drug atorvastatin in response to ROS, and sequestered proinflammatory cytokines, leading to a significant reduction in plaque area and inflammation compared to free drug or macrophage-internalized nanoparticles.
Possible Conflicts of Interest
None identified.
Identified Weaknesses
Simplified in vitro model
The in vitro study used LPS and oxLDL treatment of macrophages as models, which may not fully represent the complex in vivo environment.
High drug dose
The therapeutic efficacy study used a high dose of AT (2 mg/kg/week), which may be higher than clinically relevant doses, limiting the translatability of the findings.
Limited generalizability
The study only used female mice, which may not reflect the effects of the treatment in males.
Rating Explanation
This study presents a novel and well-designed biomimetic drug delivery system with promising results in treating atherosclerosis. The macrophage membrane coating allows the nanoparticles to evade the immune system, target inflammatory tissues, and sequester proinflammatory cytokines, leading to enhanced therapeutic efficacy. However, there are some limitations, including the simplified in vitro model and high drug dose used in the in vivo study, that prevent a rating of 5.
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File Information
Original Title:
Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
File Name:
s41467-020-16439-7.pdf
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File Size:
6.12 MB
Uploaded:
July 14, 2025 at 10:45 AM
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