Associations of place-based social determinants of health with biomarkers of Alzheimer's disease and related dementias
This study investigated how neighborhood disadvantage, social vulnerability, and environmental injustice (place-based social determinants of health, SDoH) relate to Alzheimer's disease biomarkers. It found that SDoH measures were significantly higher among Black participants compared to White participants. Crucially, these higher SDoH measures were associated with worse neuroimaging biomarkers (like lower cortical thickness and higher cerebral blood flow variability) exclusively among Black participants, not White participants.