Browse research papers in Pathology and Forensic Medicine - Medicine Discover 4 academic papers with AI-powered analysis

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Pathology and Forensic Medicine

Disease diagnosis through laboratory analysis, including anatomic pathology, clinical pathology, molecular pathology, autopsy, and the application of pathology to legal investigations

4 papers in this specialization

Papers

Applicability of ChatGPT in Assisting to Solve Higher Order Problems in Pathology

ChatGPT demonstrated a "relational" level of accuracy in answering higher-order reasoning questions in pathology, similar to a score of 4 out of 5. It could connect different concepts to provide meaningful responses, but its performance is not yet equivalent to human experts, particularly in complex or nuanced scenarios. While useful for students and academics, cautious and informed use is recommended.

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20230323-21852-6o66rf.pdf

Jul 14, 05:15 PM

Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

Hsp90 plasma levels are elevated in systemic sclerosis (SSc) patients and correlate with decreased lung function and increased inflammation. In diffuse cutaneous SSc, Hsp90 levels also correlate with skin involvement. Importantly, baseline Hsp90 levels can predict the 12-month change in lung diffusion capacity in SSc-ILD patients treated with cyclophosphamide, suggesting its potential as a biomarker for treatment response.

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s41598-020-79139-8.pdf

Jul 14, 10:38 AM

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

This study developed an injectable, temperature-sensitive hydrogel (dECM@exo) composed of decellularized extracellular matrix and adipose-derived mesenchymal stem cell exosomes for the treatment of intervertebral disc degeneration (IVDD). The dECM@exo hydrogel was shown to be biocompatible, promote matrix synthesis, and inhibit pyroptosis in nucleus pulposus cells in vitro, and it also ameliorated IVDD in a rat model in vivo.

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s12951-021-00991-5.pdf

Jul 14, 10:37 AM

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Dasatinib and Quercetin (D+Q), a senolytic drug combination, effectively slowed age-related disc degeneration in mice when administered before the onset of established degeneration. D+Q reduced senescence markers, mitigated inflammation, and preserved disc matrix composition, indicating its potential as a therapeutic strategy for early- to mid-stage disc degeneration.

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s41467-021-25453-2.pdf

Jul 14, 10:37 AM