Browse research papers in Molecular Medicine - Biochemistry, Genetics and Molecular Biology Discover 4 academic papers with AI-powered analysis

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Biochemistry, Genetics and Molecular Biology

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Molecular Medicine

The application of molecular biology to understand and treat disease, including molecular diagnostics, personalized medicine, gene therapy, drug development, and translational research from bench to bedside

4 papers in this specialization

Papers

A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex

This paper introduces Kleborate, a new bioinformatics tool for analyzing Klebsiella pneumoniae genomes. Kleborate rapidly identifies species, AMR genes, virulence factors, and other key features, providing valuable information for genomic surveillance and epidemiological studies. The tool was applied to public genome datasets, revealing trends in AMR, virulence, and the convergence of these traits.

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s41467-021-24448-3.pdf

Jul 14, 10:52 AM

AMRFinderPlus and the Reference Gene Catalog facilitate examination of the genomic links among antimicrobial resistance, stress response, and virulence

This paper describes AMRFinderPlus, an enhanced tool for identifying antimicrobial resistance, stress response, and virulence genes in bacterial genomes. AMRFinderPlus uses a curated database, HMMs, and a hierarchical naming system to accurately detect and classify genes, including point mutations. Validation tests using Salmonella datasets showed high concordance with previous results and highlighted the tool's ability to analyze closed plasmid sequences and whole-genome shotgun assemblies.

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s41598-021-91456-0.pdf

Jul 14, 10:52 AM

Multifunctional nanoparticle-mediated combining therapy for human diseases

This review explores the potential of multifunctional nanoparticles to enhance combination drug therapy for various human diseases, including cancer, cardiovascular diseases, inflammatory diseases, and neurodegenerative diseases. While preclinical studies show promise, clinical translation remains limited, and more research is needed to address challenges in targeted delivery, drug loading, and minimizing toxicity.

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s41392-023-01668-1.pdf

Jul 14, 10:52 AM

Strong, tough, ionic conductive, and freezing-tolerant all-natural hydrogel enabled by cellulose-bentonite coordination interactions

This paper introduces a strong, tough, ionic conductive, and freezing-tolerant hydrogel made from cellulose and bentonite clay. The unique interaction between these materials allows for high ionic conductivity even at sub-zero temperatures, making it suitable for flexible electronics and biomedical applications.

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s41467-022-30224-8.pdf

Jul 14, 10:52 AM