← Back

Molecular Medicine

The application of molecular biology to understand and treat disease, including molecular diagnostics, personalized medicine, gene therapy, drug development, and translational research from bench to bedside

9 papers

Papers

GADD45A suppression contributes to cardiac remodeling by promoting inflammation, fibrosis and hypertrophy

This study, primarily using a mouse knockout model and human heart cell lines, found that suppressing the GADD45A gene leads to severe cardiac problems, including inflammation, fibrosis, and an enlarged heart. Overexpressing GADD45A in human heart cells, conversely, helped prevent these adverse responses, while human patient data showed a correlation between lower GADD45A levels and increased left ventricular mass and fibrosis. The authors suggest that boosting GADD45A activity could be a therapeutic strategy to slow the progression of heart disease.

★ ★ ★ ☆ ☆
Molecular Medicine Sep 29, 04:51 PM

Gene therapy and genome editing for lipoprotein disorders

This review discusses the potential of gene therapies, specifically gene addition and gene editing, for treating lipoprotein disorders like familial hypercholesterolemia and elevated lipoprotein(a). While promising results have been seen in preclinical and early clinical trials, highlighting the potential for durable treatments that could improve adherence, further research is needed to address challenges such as off-target effects, immune responses, and the high cost of these therapies.

★ ★ ★ ★ ☆
Molecular Medicine Sep 21, 07:08 PM

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing

This study, mostly conducted in cell lines, found that targeted removal of methyl groups from the promoters of fetal hemoglobin genes can reverse their silencing in adult cells. This reactivation could be a potential therapeutic strategy for hemoglobin disorders like sickle cell disease and beta-thalassemia. Further research is needed to confirm the long-term effects and safety in vivo.

★ ★ ★ ★ ☆
Molecular Medicine Aug 18, 06:12 AM

A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex

This paper introduces Kleborate, a new bioinformatics tool for analyzing Klebsiella pneumoniae genomes. Kleborate rapidly identifies species, AMR genes, virulence factors, and other key features, providing valuable information for genomic surveillance and epidemiological studies. The tool was applied to public genome datasets, revealing trends in AMR, virulence, and the convergence of these traits.

★ ★ ★ ★ ☆
Molecular Medicine Jul 14, 10:52 AM

AMRFinderPlus and the Reference Gene Catalog facilitate examination of the genomic links among antimicrobial resistance, stress response, and virulence

This paper describes AMRFinderPlus, an enhanced tool for identifying antimicrobial resistance, stress response, and virulence genes in bacterial genomes. AMRFinderPlus uses a curated database, HMMs, and a hierarchical naming system to accurately detect and classify genes, including point mutations. Validation tests using Salmonella datasets showed high concordance with previous results and highlighted the tool's ability to analyze closed plasmid sequences and whole-genome shotgun assemblies.

★ ★ ★ ★ ☆
Molecular Medicine Jul 14, 10:52 AM

Multifunctional nanoparticle-mediated combining therapy for human diseases

This review explores the potential of multifunctional nanoparticles to enhance combination drug therapy for various human diseases, including cancer, cardiovascular diseases, inflammatory diseases, and neurodegenerative diseases. While preclinical studies show promise, clinical translation remains limited, and more research is needed to address challenges in targeted delivery, drug loading, and minimizing toxicity.

★ ★ ★ ☆ ☆
Molecular Medicine Jul 14, 10:52 AM

Strong, tough, ionic conductive, and freezing-tolerant all-natural hydrogel enabled by cellulose-bentonite coordination interactions

This paper introduces a strong, tough, ionic conductive, and freezing-tolerant hydrogel made from cellulose and bentonite clay. The unique interaction between these materials allows for high ionic conductivity even at sub-zero temperatures, making it suitable for flexible electronics and biomedical applications.

★ ★ ★ ★ ☆
Molecular Medicine Jul 14, 10:52 AM