Browse research papers in Cancer Research - Biochemistry, Genetics and Molecular Biology Discover 4 academic papers with AI-powered analysis

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Biochemistry, Genetics and Molecular Biology

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Cancer Research

The multidisciplinary study of cancer biology, including carcinogenesis, tumor progression, metastasis, cancer genetics, immunology, and the development of diagnostic, preventive, and therapeutic strategies

4 papers in this specialization

Papers

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox

This study, primarily conducted in cancer cell lines, suggests that peroxisomes play a role in maintaining mitochondrial redox homeostasis by transferring reactive oxygen species (ROS) through a contact site mediated by the proteins ACBD5 and PTPIP51. This contact appears to increase during mitochondrial oxidative stress, facilitating ROS transfer and protecting mitochondrial health.

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DiGiovanni et al. - 2025 - ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox.pdf

Jul 19, 04:23 PM

Inflammation and tumor progression: signaling pathways and targeted intervention

Cancer development and its response to therapy are significantly influenced by inflammation, which can either promote or suppress tumor progression. Chronic inflammation often aids tumor progression and resistance to treatment, whereas acute inflammatory responses can stimulate anti-tumor immunity.

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s41392-021-00658-5.pdf

Jul 14, 05:08 PM

Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer

By analyzing gene expression data from thousands of breast cancer samples, this study identified and ranked the genes with the highest prognostic power in two clinically relevant cohorts: estrogen receptor-positive/ERBB2-negative patients treated with chemotherapy and basal breast tumors receiving chemotherapy. This ranking helps prioritize promising biomarker candidates for future research and clinical validation.

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

This study identifies a novel mechanism by which the oxygen sensor PHD1 regulates muscle protein synthesis. PHD1 stabilizes leucyl tRNA synthetase (LRS), a leucine sensor, enhancing mTORC1 activation and protein synthesis in response to leucine. This interaction is amplified during periods of low oxygen and amino acids, ensuring a robust response when nutrients are restored. The relevance of this pathway is highlighted by the observation of reduced PHD1 and LRS activity in older adults with anabolic resistance.

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s41467-019-13889-6.pdf

Jul 14, 10:44 AM