Browse research papers in Biotechnology - Biochemistry, Genetics and Molecular Biology Discover 4 academic papers with AI-powered analysis

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Biochemistry, Genetics and Molecular Biology

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Biotechnology

The application of biological systems and organisms to develop products and technologies, including genetic engineering, synthetic biology, biopharmaceuticals, industrial biotechnology, and agricultural biotechnology applications

4 papers in this specialization

Papers

Optogenetics for light control of biological systems

Optogenetics uses light and genetic engineering to control the activity of specific cells within complex tissues. This technique employs microbial photoreceptors to make naturally light-insensitive cells photosensitive and precisely controllable, enabling new research and therapeutic possibilities across various fields like neuroscience, cardiology, and plant science.

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

Teixobactin kills bacteria through a two-pronged attack: it inhibits cell wall synthesis by binding to lipid II and disrupts bacterial membranes by forming supramolecular fibrils that displace phospholipids and thin the membrane. This dual action makes teixobactin highly effective against multidrug-resistant Gram-positive bacteria.

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s41586-022-05019-y.pdf

Jul 14, 10:52 AM

Tracing animal genomic evolution with the chromosomal-level assembly of the freshwater sponge Ephydatia muelleri

This paper presents a chromosome-level assembly of the freshwater sponge Ephydatia muelleri, revealing a larger genome size and higher gene count than most animals, attributed to gene duplication. The study also provides evidence for conserved synteny with other metazoans and explores genomic changes related to freshwater adaptation, including gene duplication and positive selection.

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s41467-020-17397-w.pdf

Jul 14, 10:52 AM

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

This study demonstrates that engineered E. coli Nissle (SYNB1891) can be used to deliver a STING agonist (CDA) directly to tumor-infiltrating APCs, resulting in potent anti-tumor immunity in murine models. SYNB1891 activates STING signaling, triggers proinflammatory cytokine production, and generates immunological memory, resulting in durable tumor rejection in a proportion of treated mice.

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s41467-020-16602-0.pdf

Jul 14, 10:52 AM