Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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mRNA Vaccines and Transcriptome Changes: A Small Study on Adverse Events and Cancer

This very small study (10 participants) analyzed gene expression changes in people who developed new-onset adverse events or cancer after mRNA COVID-19 vaccination. The researchers found changes in gene expression related to mitochondrial function, immune response, and cell growth, but the tiny sample size makes it impossible to draw any firm conclusions.

Possible Conflicts of Interest

The authors disclose that Neo7Bioscience, a private biotechnology company, provided data interpretation assistance, and the McCullough Foundation provided independent support for scientific investigation. This could raise concerns about potential bias in the interpretation of the results.

Identified Weaknesses

Extremely small sample size

With only 3 participants in the adverse events group and 7 in the cancer group, the study is severely underpowered and cannot reliably establish causal links between vaccination and the observed transcriptomic changes. The small sample size makes the findings highly susceptible to random variation and limits the generalizability of the results.

Lack of pre-vaccination data

Without baseline gene expression data from the participants before vaccination, it's impossible to determine whether the observed changes are truly caused by the vaccine or pre-existed. This makes it difficult to isolate the specific effects of the vaccine on gene expression.

Correlation does not equal causation

While the study identifies correlations between vaccination and gene expression changes, it cannot definitively prove a causal relationship. Other factors, such as individual genetic predispositions, environmental exposures, or other health conditions, could also contribute to the observed changes.

Lack of a proper control group

The control group of "healthy individuals" isn't well-defined and may not be directly comparable to the patient groups in terms of age, health status, or other relevant factors. A more rigorous study design would include a control group of unvaccinated individuals with similar characteristics to the patient groups.

Rating Explanation

The extremely small sample size is the primary reason for the low rating. While the study explores an important topic, the limited number of participants makes it difficult to draw any meaningful conclusions about the effects of mRNA vaccines on gene expression.

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