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Health Sciences › Medicine › Internal Medicine
Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
To Clot or Not to Clot: Anticoagulation Advice for COVID-19
The guidance recommends pharmacologic VTE prophylaxis for all hospitalized COVID-19 patients, suggests increased doses for critically ill patients, and advises against routine extended prophylaxis post-discharge. It also recommends using anti-Xa assays to monitor unfractionated heparin and suggests against using D-dimer to guide therapy.
Possible Conflicts of Interest
Some authors disclosed receiving grant funding or consulting fees from pharmaceutical companies.
Identified Weaknesses
Limited Evidence
This guidance is based on expert opinion and limited data from observational studies in the context of a rapidly evolving pandemic. The recommendations are interim and subject to change as more data become available.
Potential for Expert Bias
The guidance acknowledges the potential for bias due to the shared experiences and opinions of the authors, who are all experts in anticoagulation.
Limited Subgroup Guidance
The guidance lacks specific recommendations for certain subpopulations, such as pregnant women and children, and relies on existing guidelines or collaboration with specialists.
Rating Explanation
This paper provides important interim guidance on a critical issue during the COVID-19 pandemic. Although based on expert opinion and limited data, it offers a structured and rational approach to anticoagulation in COVID-19 patients, addressing key questions and acknowledging limitations. The disclosed conflicts of interest are noted but don't appear to significantly detract from the value of the guidance.
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Topic Hierarchy
File Information
Original Title:
Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum
File Name:
s11239-020-02138-z.pdf
[download]
File Size:
0.49 MB
Uploaded:
July 14, 2025 at 10:31 AM
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