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Health Sciences › Health Professions › Emergency Medical Services
Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Gut Buddies to the Rescue? Probiotics Show Promise for Asthma, But More Work Needed!
This study found that probiotics, and to a lesser extent prebiotics, could reduce allergic asthma inflammation and improve airway hyperresponsiveness in a mouse model. This effect was linked to modulation of immune responses, particularly by balancing Th1/Th2 cytokines and regulating the TLR4/NF-kB signaling pathway.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Lack of a chronic model
The study lacks a chronic model of airway inflammation, limiting the generalizability of the findings to chronic asthma conditions.
Missing protein and phosphorylation data
The absence of protein and phosphorylation data for the signaling pathways makes it difficult to fully elucidate the underlying molecular mechanisms.
Lack of pathway verification
The lack of genetic gain/loss of function models or pharmacological treatments to verify the pathway weakens the strength of the mechanistic claims.
Missing control groups
The study didn't include control groups treated with only OVA or LPS, making it difficult to isolate the specific effects of each component.
Unclear role of TLR4
The study did not investigate the role of TLR4 in the observed effects, leaving open the question of whether probiotics can inhibit asthma pathophysiology independently of TLR4.
Rating Explanation
The study demonstrates some positive effects of probiotics and prebiotics on allergic asthma inflammation in a mouse model, but several methodological limitations prevent a higher rating. The lack of certain control groups, chronic models, and deeper mechanistic investigations weaken the overall impact. While the findings are promising, further research is needed to confirm these effects and explore the underlying mechanisms in more detail.
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File Information
Original Title:
Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway
File Name:
s12967-022-03337-3.pdf
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File Size:
1.51 MB
Uploaded:
July 14, 2025 at 10:49 AM
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