Preventing acute kidney injury and its longer-term impact in the critically ill

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Preventing Kidney Injury in Critical Care: A Review of Strategies

This narrative review discusses strategies for preventing acute kidney injury (AKI) in critically ill patients, including biomarkers for early diagnosis, discussion of AKI-CKD transition, and the selection of appropriate endpoints for prevention trials. The review highlights the importance of prevention due to AKI's impact on short- and long-term outcomes and emphasizes implementing proven strategies in clinical practice.

Possible Conflicts of Interest

Some authors declared financial ties to pharmaceutical and medical device companies related to AKI diagnosis and treatment.

Identified Weaknesses

Narrative review

Narrative reviews lack the systematic and rigorous methodology of other review types like systematic reviews and meta-analyses. This can lead to selection bias and potentially skewed representations of the evidence base.

Limited scope

The review focuses primarily on AKI prevention in cardiac surgery patients, limiting the generalizability of its findings to other clinical settings and AKI etiologies.

Lack of in-depth discussion on management and RRT

Excluding a discussion on AKI management and renal replacement therapy provides an incomplete picture of AKI care for critically ill patients.

Rating Explanation

This is a comprehensive review on a clinically significant topic, summarizing valuable information on AKI prevention strategies. However, the limitations inherent to its narrative nature and specific focus on cardiac surgery warrant a rating of 4 rather than 5.

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