The review discusses recent progress in periodontal regeneration using biomaterials, focusing on bio-inspired scaffolding materials and controlled drug delivery. It highlights the challenges in reconstructing the complex periodontal structure and controlling mineralization homeostasis, while emphasizing the need for further research to improve the long-term stability of regenerated periodontal tissues.

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This is a strong review that summarizes recent advances in periodontal regeneration from a biomaterial perspective. It provides a comprehensive overview of different biomaterials, scaffolding designs, and drug delivery systems, highlighting the development of advanced bio-inspired materials and temporospatial control of drug delivery. The review also identifies challenges and future perspectives for the field. However, the lack of critical appraisal of included studies and limited clinical evidence for some interventions limit the strength of the conclusions.