The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health
Overview
Paper Summary
This study explored the relationship between genetic variation and protein levels in human kidneys, mostly of European descent. Researchers identified numerous protein quantitative trait loci (pQTLs) and expression QTLs (eQTLs), indicating genetic variants associated with specific protein levels and gene expression. While this is correlational data, the findings offer potential avenues for understanding kidney health and disease.
Explain Like I'm Five
Scientists studied proteins and genes in human kidneys to see how variations in DNA affect kidney health. They found links between specific genes and kidney protein levels, suggesting some genes could influence kidney-related diseases.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This study provides valuable insights into kidney function and disease by integrating proteomic and genomic data. The methodology is generally strong, using advanced techniques like TMT labeling and mass spectrometry. While the focus on correlation and limited generalizability to diverse populations are notable weaknesses, the findings are still valuable, justifying a rating of 4. The lack of completely transparent sample sizes in the supplementary material slightly lowers the rating.
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