The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health

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Conflicts of Interest

Identified Weaknesses

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Paper Summary

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Kidney Genes and Proteins: Exploring the Links (Mostly in Europeans)

This study explored the relationship between genetic variation and protein levels in human kidneys, mostly of European descent. Researchers identified numerous protein quantitative trait loci (pQTLs) and expression QTLs (eQTLs), indicating genetic variants associated with specific protein levels and gene expression. While this is correlational data, the findings offer potential avenues for understanding kidney health and disease.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Correlation does not equal causation

The study primarily focuses on correlations, which do not necessarily imply direct causation. Further research is needed to establish causal relationships.

Limited generalizability due to sample population

The study uses samples mostly of European descent, so the findings may not be generalizable to other populations.

Unclear full sample size

The supplementary materials don't clearly state the sample size for all analyses, making it difficult to fully assess the statistical power and robustness of the findings.

Rating Explanation

This study provides valuable insights into kidney function and disease by integrating proteomic and genomic data. The methodology is generally strong, using advanced techniques like TMT labeling and mass spectrometry. While the focus on correlation and limited generalizability to diverse populations are notable weaknesses, the findings are still valuable, justifying a rating of 4. The lack of completely transparent sample sizes in the supplementary material slightly lowers the rating.

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