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Physical SciencesPhysics and AstronomyAtomic and Molecular Physics, and Optics

A fluorescent-protein spin qubit

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Overview

Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary

Paperzilla title
A Glowing Protein Becomes a Quantum Sensor in Living Cells!
This study presents a genetically encodable fluorescent protein, EYFP, as an optically addressable spin qubit for nanoscale magnetic field sensing inside living cells. The researchers demonstrated coherent control and readout of the qubit's spin state at both cryogenic and room temperatures, although with lower contrast at room temperature. They also observed a coherence time of up to 16 microseconds under specific decoupling sequences and expressed the protein in both bacterial and mammalian cells, maintaining its functionality.

Possible Conflicts of Interest

J.S.F., B.S.S., D.D.A., and P.C.M. are inventors on a pending patent application related to fluorophore-based spin qubits.

Identified Weaknesses

Low room-temperature contrast
The demonstration at room temperature had limited contrast, which could hinder sensitivity in practical applications.
Low photon readout
The number of photons collected for readout is low, limiting the sensitivity.
Photobleaching
The sensor is sensitive to photobleaching, reducing its effectiveness.
No fusion protein experiments
While genetic encoding allows for deterministic targeting, actual experiments in fusion proteins need to be done to ensure the functionality of the sensor is preserved.
Unknown relaxation mechanism
The exact relaxation mechanisms of the spin-lattice relaxation have not been identified.

Rating Explanation

This research demonstrates a novel application of fluorescent proteins as qubits, opening up new avenues for biosensing and intracellular measurements. The genetic encodability of the sensor offers a unique advantage for targeted studies. Despite some current limitations like photobleaching and low photon readout, the potential for improvement and the innovative nature of the work warrant a strong rating.

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File Information

Original Title:
A fluorescent-protein spin qubit
File Name:
paper_516.pdf
[download]
File Size:
6.04 MB
Uploaded:
August 22, 2025 at 06:57 AM
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