Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis
Overview
Paper Summary
Gallic acid combined with low-level laser irradiation showed increased anticancer effects against breast and melanoma cancer cells in vitro compared to gallic acid alone. This synergistic effect might involve increased ROS production, decreased GPX4 activity, and enhanced lipid peroxidation, suggesting contributions from apoptosis and ferroptosis pathways.
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Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
The study presents interesting in vitro results suggesting a synergistic anticancer effect of gallic acid and low-level laser irradiation. However, the lack of in vivo validation, limited mechanistic understanding, and absence of long-term effect assessments significantly limit the impact and clinical relevance of the findings, thus justifying an average rating of 3.
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