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Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology
Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis
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Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Shining a Red Light on Cancer: Gallic Acid and Laser Tag-Team Against Tumors (But Only in a Petri Dish)
Gallic acid combined with low-level laser irradiation showed increased anticancer effects against breast and melanoma cancer cells in vitro compared to gallic acid alone. This synergistic effect might involve increased ROS production, decreased GPX4 activity, and enhanced lipid peroxidation, suggesting contributions from apoptosis and ferroptosis pathways.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Lack of in vivo studies
The study uses only in vitro models, which do not fully represent the complexity of cancer in living organisms. The lack of in vivo studies prevents assessing the actual effectiveness and safety of the proposed treatment.
Limited mechanistic understanding
The study does not fully elucidate the mechanisms underlying the observed synergistic effects of GA and low-level laser irradiation. Further research is needed to understand the precise interplay between these two modalities and how they contribute to cell death.
No long-term or side effect assessments
The study lacks investigation of potential long-term effects of the combined treatment and potential side effects on healthy cells. Assessing these aspects is crucial before considering clinical applications.
Rating Explanation
The study presents interesting in vitro results suggesting a synergistic anticancer effect of gallic acid and low-level laser irradiation. However, the lack of in vivo validation, limited mechanistic understanding, and absence of long-term effect assessments significantly limit the impact and clinical relevance of the findings, thus justifying an average rating of 3.
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Topic Hierarchy
Domain:
Life Sciences
File Information
Original Title:
Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis
File Name:
s12935-020-1100-y.pdf
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File Size:
1.90 MB
Uploaded:
July 14, 2025 at 11:20 AM
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