This updated practice recommendation emphasizes the subclavian vein as the preferred site for central venous catheter insertion in ICU settings to reduce infection risk. Essential practices include using chlorhexidine dressings, maximal sterile barrier precautions at insertion, and daily review of catheter necessity, while antimicrobial catheters and lock therapy are suggested for specific situations.

Several authors disclosed financial relationships with medical device companies or received funding for research related to infection prevention. While these disclosures were made and reviewed by SHEA and IDSA, potential biases cannot be entirely ruled out.

This practice recommendation provides updated, comprehensive guidance on preventing CLABSIs, based on a substantial review of literature. The recommendations are generally well-supported by evidence and address key aspects of CLABSI prevention. Although some limitations exist (e.g., lack of catheter-specific recommendations, inclusion of older studies), the overall quality and relevance of the document warrant a strong rating.