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Life Sciences › Immunology and Microbiology › Microbiology
Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts
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Conflicts of Interest
Identified Weaknesses
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Paper Summary
Paperzilla title
Good Gut Bugs: Mycoplasma Might Just Be a Salmon's Best Friend
The study found a dominance of Mycoplasma in the gut microbiomes of three salmonid species, suggesting two novel candidate species. Genomic analyses suggests this Mycoplasma has adapted to the intestinal environment of salmonids and may provide benefits to the host including B vitamin biosynthesis and ammonia detoxification.
Possible Conflicts of Interest
One of the authors is affiliated with Lerøy Seafood Group ASA. However, this potential conflict of interest is likely minimal based on the content of the study.
Identified Weaknesses
Limitations in use of MAGs
The study acknowledges limitations in the use of metagenomic assembled genome technology due to potential false positives. Though manual curation is used to minimize limitations, it is important to keep this in mind.
Lack of positive control for probe design in fluorescence microscopy
Though biomass was monitored, the study was not able to culture salmonid-associated Mycoplasma species and therefore lacked a proper positive control in their probe design for fluorescence microscopy. This resulted in an inability to verify Mycoplasma identity in these fluorescence microscopy analyses and introduces uncertainty regarding the signals.
Age of fish samples may not be generalizable
The samples of rainbow trout were limited to relatively young fish raised in a recirculating aquaculture system. These factors may influence the composition and functional potential of the microbiome, and may not be generalizable to older rainbow trout in other environments.
Not fully saturated metagenomics
Metagenomics were not fully saturated for all sample types, which introduces uncertainties regarding the completeness of genomes found in the samples and their functional potential.
Rating Explanation
This is a generally strong paper in terms of methodology and novelty. However, several minor weaknesses prevent it from reaching a full 5-star rating.
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File Information
Original Title:
Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts
File Name:
s42003-021-02105-1.pdf
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File Size:
4.28 MB
Uploaded:
July 14, 2025 at 11:11 AM
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