Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder
Overview
Paper Summary
This study found a consistent pattern of reduced blood flow in certain brain areas in people with major depressive disorder (MDD) across multiple datasets, which was reflected in a functional MRI measure called regional homogeneity (ReHo). However, the effect sizes were small, meaning the differences, while consistent, were not large, and the study primarily used a white, middle-aged population sample.
Explain Like I'm Five
Brain scans show some areas of the brain might be less active in people with depression. These differences are small but show up consistently across different studies and scanning methods.
Possible Conflicts of Interest
Dr. Keator reported receiving a salary for clinical neuroimaging support from Amen Clinics Inc. and neuroimaging research support from Change Your Brain Foundation. Dr. Soares reported receiving grants from several pharmaceutical companies and having advisory board roles with others. Dr. Hong reported receiving grants from the NIH and research funding or consulting fees from numerous pharmaceutical companies.
Identified Limitations
Rating Explanation
The study uses a large, multi-dataset approach to investigate a relevant topic in depression research. However, the small effect sizes, limited sample diversity, lack of direct clinical implications, and potential conflicts of interest limit the impact and generalizability of the findings. The rating is lowered due to potential COI.
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