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Health Sciences › Medicine › Infectious Diseases
A pneumonia outbreak associated with a new coronavirus of probable bat origin
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Overview
Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
A New Bat-Related Coronavirus Causes Pneumonia Outbreak in Wuhan
A novel coronavirus, 2019-nCoV, was identified as the causative agent of a pneumonia outbreak in Wuhan, China. Genome sequencing revealed close similarity to bat coronaviruses, suggesting a zoonotic origin, and identified the same cell entry receptor (ACE2) as SARS-CoV.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Small sample size
The sample size of seven patients is small, limiting the generalizability of the findings.
Lack of randomization and blinding
The lack of randomization and blinding could introduce bias into the study.
Reliance on PCR and serological tests
The study relies on PCR and serological tests, which may not be perfectly accurate.
Lack of Koch's postulates
The study does not fulfill Koch's postulates, which are the gold standard for establishing a causal relationship between a microorganism and a disease.
Limited exploration of transmission routes
The study does not fully explore all possible transmission routes of the virus.
Rating Explanation
This study represents a significant contribution to understanding the origins and characteristics of the 2019-nCoV virus. Despite some limitations, the study presents compelling evidence linking the virus to a bat origin and identifying ACE2 as the cellular entry receptor. The study's rapid publication and detailed findings were crucial for the global response to the emerging pandemic.
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Topic Hierarchy
File Information
Original Title:
A pneumonia outbreak associated with a new coronavirus of probable bat origin
File Name:
s41586-020-2012-7.pdf
[download]
File Size:
10.34 MB
Uploaded:
July 14, 2025 at 07:02 AM
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