Severe Saprochaete capitata fungemia presenting as micafungin breakthrough hepatosplenic lesions in an immunocompromised patient: case report

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Paper Summary

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Rare Fungal Infection Leads to Severe Complications in Immunocompromised Patient: A Case Report

This case report describes a 70-year-old immunocompromised patient who developed a severe, disseminated Saprochaete capitata infection after initial micafungin prophylaxis failed. The infection led to hepatosplenic lesions and required a combination of antifungal therapies for successful treatment.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Case Report

Case reports provide limited generalizability to larger populations. More research is needed to understand the prevalence, risk factors, and optimal treatment strategies for S. capitata infections.

Lack of Standardized Antifungal Susceptibility Testing

The absence of established breakpoints for S. capitata makes it challenging to interpret antifungal susceptibility results and guide treatment decisions.

Rating Explanation

This well-written case report details a rare and serious fungal infection. While limited in generalizability due to its nature as a single case study, it provides valuable insights for clinicians and researchers in managing this emerging pathogen. The authors acknowledge the limitations associated with the lack of standardized antifungal susceptibility testing.

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