Pathophysiology of musculoskeletal pain: a narrative review
Overview
Paper Summary
This review summarizes the different ways bone, joint, and muscle pain become chronic. It describes how nerves, inflammation, glial cells, and even social and emotional factors can contribute to long-lasting pain.
Explain Like I'm Five
Chronic musculoskeletal pain (excluding bone cancer pain) affects a large portion of the population and has significant social and economic impact. This review summarizes how pain signals in bones, joints, and muscles get amplified and lead to chronic pain.
Possible Conflicts of Interest
One author is a member of the journal's editorial board. Funding for the research was provided by the 'Paolo Procacci Foundation-ONLUS.'
Identified Limitations
Rating Explanation
This is a comprehensive and well-written review that covers a wide range of topics related to musculoskeletal pain. It summarizes complex information effectively and provides helpful insights into the underlying mechanisms and contributing factors to chronic pain. However, as a narrative review, it doesn't present any new original research and might be slightly outdated. The discussion on some aspects could also be further expanded.
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