Lack of strong empirical evidence
The review relies heavily on opinion and lacks strong empirical evidence to support its claims. The proposed "revised ladder" isn't rigorously validated.
Narrow focus and limited scope
The focus is very narrow, primarily addressing opioid use in CNCP and not exploring broader pain management strategies in sufficient detail. The dismissal of the WHO ladder seems premature without offering a thoroughly researched alternative.
Oversimplification of pain management
The paper doesn't adequately address the complexities of pain management, such as individual patient variability, different pain mechanisms, or the role of psychological factors.
Lack of practical implementation guidance
The review doesn't offer specific, measurable recommendations for implementation of the revised ladder, making it difficult to translate into practice. It lacks clear guidance on how to integrate integrative medicine and interventional therapies effectively.