Limited in-vivo and real-world application testing
The study primarily focuses on in-vitro experiments, and while some preliminary tests were conducted with an electric toothbrush, the real-world effectiveness of piezo-catalysis in daily oral hygiene routines needs further investigation. Long-term effects, optimal BTO concentration in toothpaste, and potential interactions with other oral hygiene products require additional research.
Lack of long-term safety and efficacy data
While the study demonstrates the whitening effect and lack of immediate enamel damage, long-term effects on tooth structure and oral health are unknown. Further research is needed to assess the cumulative impact of piezo-catalysis over extended periods.
Limited range of staining agents tested
The study uses a limited set of staining agents, which may not represent the full spectrum of tooth discoloration causes. The effectiveness of piezo-catalysis on other types of stains, such as those caused by certain medications or intrinsic discoloration, requires further evaluation.
Incomplete comparison with other whitening methods
The comparison with hydrogen peroxide is limited to a high concentration (30%) and a lower concentration (3%), but does not explore other commonly used whitening agents or concentrations. A more comprehensive comparison with existing whitening methods is needed.