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Health Sciences › Health Professions › Complementary and Manual Therapy
Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Seaweed Fucoidan Fights Back Against Chemo's Immune System K.O.
Fucoidan from Laminaria japonica seaweed improved immune function and gut health in mice treated with cyclophosphamide, a common chemotherapy drug that suppresses the immune system. It boosted immune cell activity, cytokine levels, and beneficial gut bacteria, suggesting it could be a useful supplement to reduce chemotherapy side effects.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Small sample size
The sample size is small (n=8 per group) and limits the generalizability of the findings.
Limited to male mice
The study only used male mice, which may not reflect the effects of LF on female mice.
Lack of long-term data
The study did not investigate the long-term effects of LF supplementation.
Limited mechanistic insights
The mechanisms by which LF modulates the immune response and gut microbiota are not fully elucidated.
Rating Explanation
This study provides strong evidence for the immunomodulatory and gut microbiota-regulating effects of Laminaria japonica fucoidan in a mouse model of immunosuppression. The methodology is generally sound, but some limitations, such as the small sample size, prevent a higher rating. There are no obvious conflicts of interest.
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File Information
Original Title:
Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice
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July 14, 2025 at 11:23 AM
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