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Life Sciences › Immunology and Microbiology › Microbiology
Phylogenomics of expanding uncultured environmental Tenericutes provides insights into their pathogenicity and evolutionary relationship with Bacilli
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Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Gut bugs without walls: a Tenericute tale of hydrogen and missing links!
The study discovered several novel Tenericutes lineages in various environments, including the human gut. Phylogenomic analysis placed these lineages close to other Bacilli groups, blurring the lines between Tenericutes and Bacilli. The two main human gut lineages, RF39 and RFN20, were predicted to be hydrogen producers and may play a role in gut homeostasis.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Lack of experimental validation
The study relies heavily on bioinformatic analysis of genomes and lacks experimental validation. This limits the strength of the conclusions drawn about metabolic function and adaptive strategies, which are based on gene presence/absence rather than demonstrated activity.
Genome database bias
While the study analyzes a large number of genomes, it acknowledges a bias towards pathogenic and commensal species within the available data. This skews the representation of environmental Tenericutes lineages and may not fully capture their diversity and ecological roles.
Hypothetical metabolic models
The metabolic models proposed for RFN20 and RF39, particularly hydrogen production, are hypothetical and need experimental verification. The study identifies genes potentially involved in these pathways but doesn't confirm their activity or the actual production of hydrogen.
Rating Explanation
This study significantly expands our understanding of Tenericutes diversity, particularly within environmental lineages. The phylogenomic analysis clarifies relationships with Bacilli and sheds light on potential metabolic adaptations in the human gut. While limited by the lack of experimental validation and potential database bias, the insights provided are valuable and warrant further investigation. Thus, rated as a 4 for its strong bioinformatic analysis and novel insights despite some limitations.
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File Information
Original Title:
Phylogenomics of expanding uncultured environmental Tenericutes provides insights into their pathogenicity and evolutionary relationship with Bacilli
File Name:
s12864-020-06807-4.pdf
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File Size:
1.78 MB
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July 14, 2025 at 11:11 AM
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