Copy Number Change of the NDM-1 Sequence in a Multidrug-Resistant Klebsiella pneumoniae Clinical Isolate
Overview
Paper Summary
This study found that a multidrug-resistant *Klebsiella pneumoniae* bacterium, KPX, isolated from a patient, carries multiple copies of the NDM-1 gene, responsible for antibiotic resistance. The copy number of this gene dynamically increases under antibiotic selection and decreases when antibiotics are removed, revealing a unique adaptation mechanism in the bacteria.
Explain Like I'm Five
A bacteria resistant to most antibiotics carries multiple copies of a resistance gene, NDM-1, which can increase or decrease depending on antibiotic presence. This dynamic behavior makes it harder to fight.
Possible Conflicts of Interest
None identified.
Rating Explanation
Solid methodology and interesting findings on NDM-1 gene copy number variation. Well-written and clear presentation. No obvious limitations or flaws.
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