Copy Number Change of the NDM-1 Sequence in a Multidrug-Resistant Klebsiella pneumoniae Clinical Isolate

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Paper Summary

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NDM-1 Resistance Gene in Bacteria: Like a Photocopier on Steroids!

This study found that a multidrug-resistant *Klebsiella pneumoniae* bacterium, KPX, isolated from a patient, carries multiple copies of the NDM-1 gene, responsible for antibiotic resistance. The copy number of this gene dynamically increases under antibiotic selection and decreases when antibiotics are removed, revealing a unique adaptation mechanism in the bacteria.

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None identified.

Rating Explanation

Solid methodology and interesting findings on NDM-1 gene copy number variation. Well-written and clear presentation. No obvious limitations or flaws.

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