Supplementary Information for The Virtual Lab of AI Agents Designs New SARS-CoV-2 Nanobodies
Overview
Paper Summary
This study describes a virtual lab where AI agents designed nanobodies against new SARS-CoV-2 variants by modifying existing ones, utilizing machine learning tools like ESM and AlphaFold. The research demonstrates the importance of prompt engineering, finding that the agents' tool selection is highly sensitive to how questions are phrased. Finetuning the AI agents allowed them to learn about newer variants that appeared after their initial training data cutoff.
Explain Like I'm Five
A virtual lab with AI agents designed nanobodies against COVID variants by modifying existing ones and using machine learning tools like ESM and AlphaFold. Testing different ways to prompt the AIs, showed they are sensitive to what users ask for.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This supplementary information details a novel approach using AI agents for nanobody design, demonstrating a promising application of AI in biomedical research. It clearly outlines the methodology and its limitations, including the dependence on pre-trained models and the importance of prompt engineering. The findings contribute to our understanding of how AI agents can be effectively used in scientific discovery, making it a valuable addition to the field. The reliance on existing nanobodies for modification somewhat limits its innovativeness, thus preventing a rating of 5.
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