1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

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Conflicts of Interest

Identified Weaknesses

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Paper Summary

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Mosquitoes Spread Dengue: A Genomic Journey from Africa to the World

This study analyzed 1206 genomes of Aedes aegypti mosquitoes, revealing that the invasive subspecies (Aaa) likely emerged in the Americas after the Atlantic slave trade and spread globally. The research also highlights contemporary admixture between Aaa and the ancestral African subspecies (Aaf), including the sharing of insecticide-resistance mutations, posing a threat to dengue control efforts in Africa.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Oversimplification of complex evolutionary history

While the study provides strong evidence for the proposed Aaa origin and spread, the complexities of mosquito evolution and migration may involve more nuanced scenarios than a simple linear progression.

Limited functional validation of identified genes

Although the study identifies genes potentially involved in adaptation, functional validation is needed to confirm their role in host preference and other traits.

Indirect inferences about historical events

The study relies on genetic data and models to infer historical events like the origin and spread of Aaa, which are subject to limitations and uncertainty.

Rating Explanation

This study represents a significant contribution to understanding the evolutionary history and global spread of Aedes aegypti. The large-scale genomic analysis, combined with demographic modeling and admixture analysis, provides valuable insights into the origin and adaptation of the invasive subspecies. While some limitations exist regarding the interpretation of historical events and the lack of functional validation, the study's methodology is rigorous and the findings are well-supported by data, warranting a rating of 4.

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